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News, Calendars, and Events » Calendars » Master Calendar » Biochemistry and Molecular & Cellular Biology, Department of
Seminar Series: Dr. Yehia Mechref
Schedule information
Event Seminar Series: Dr. Yehia Mechref
When Tuesday, September 24, 2013 from 12:00pm to 1:00pm
Where Basic Science Building 341 (Library)
Event details
Details 'Understanding Breast Cancer Brain Metastasis through Glycomics and Glycoproteomics'

Yehia Mechref, Ph.D.
Associate Professor
Department of Chemistry and Biochemistry
Texas Tech University

Abstract: Breast cancer (BC), the most deadly of cancers among women, is a molecularly heterogeneous disease. Brain metastases (BM) are common advanced metastatic breast cancer and contribute significantly to morbidity and mortality from the disease. Understanding the biological attributes of metastatic breast cancer cells which are able to extravasate through the blood-brain barrier is necessary to develop diagnostic tests to predict brain metastases and for developing novel approaches to treatment or prevention of brain metastases. Glycosylation of proteins and lipids plays a role in many key biological functions such as immune response, cell development, cellular differentiation/adhesion and host-pathogen interactions. Recently, we have demonstrated a correlation between cancer and aberrant glycosylation. Our data suggest that breast cancer cells that have a predilection to brain metastases have a unique glycomic and glycoproteomic signatures that might be partially responsible for the ability of these cells to cross the blood-brain barrier. In this presentation, the utility of recently developed sensitive MS-based glycomic and glycoproteomic approaches to define the glycomic and glycoproteomic signatures of different breast cancer cell lines will be presented. The correlation between glycomic and glycoproteomic signatures to clinicopathological characteristics of different breast cancer cell lines will be also presented. The ability to use these glycomic and glycoproteomic signatures to predict breast cancer patient potential to develop bran metastasis will be discussed. Our overarching goal is to define glycomic/glycoproteomic signatures of breast cancers with a predilection to form brain metastases that may enable development of diagnostic assays that identify women at high risk of breast cancer brain metastases.
Access » This event has been marked as open to the public.
Contact Juanita Chipani Biochemistry and Molecular & Cellular Biology office, x71512
Sponsors Department of Biochemistry and Molecular & Cellular Biology
Calendar Biochemistry and Molecular & Cellular Biology, Department of
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