Georgetown University home page Search: Full text search Site Index: Find a web site by name or keyword Site Map: Overview of main pages Directory: Find a person; contact us About this site: Copyright, disclaimer, policies, terms of use Georgetown University home page Home page for prospective students Home page for current students Home page for alumni and alumnae Home page for family and friends Home page for faculty and staff
Navigation bar Navigation bar
Navigation bar
News, Calendars, and Events » Calendars » Master Calendar » Biochemistry and Molecular & Cellular Biology, Department of
Seminar Series: Dr. Jeremy Selengut
Schedule information
Event Seminar Series: Dr. Jeremy Selengut
When Tuesday, November 19, 2013 from 12:00pm to 1:00pm
Where Basic Science Building 341 (Library)
Event details
Details 'Practical Solutions for Intractable Problems in Bioinformatics'

Jeremy Selengut, Ph.D.
Associate Research Scientist
Institute for Advanced Computer Studies
University of Maryland

Abstract: Techniques developed and assumptions made during the early years of the genomic revolution can be stretched to the breaking point in the current era of big data. Two methods, phylogenetic profiling and shotgun sequencing assembly, work well on what we would now consider 'small' datasets, but become intractable and/or unreliable when many genomes are considered simultaneously. These examples will be used to illustrate how choices of methods made when it was possible to consider all of the data can handcuff expansion of those techniques when that is no longer practical. It has been said that the key to success in bioinformatics is knowing what data can be ignored. Partial Phylogenetic Profiling (PPP) and mini-HMM analysis of metagenomes are two techniques that sidestep the bottlenecks of processing big data by discarding foundational assumptions that are no longer tenable. PPP allows researchers to identify proteins that work together in many genomes without first defining a global set of protein families. Mini-HMMs allow the analysis of hundreds of genomes simultaneously based on known marker genes without first having to correctly assemble all of the shotgun data.
Access » This event has been marked as open to the public.
Contact Juanita Chipani Biochemistry and Molecular & Cellular Biology office, x71512
Sponsors Department of Biochemistry and Molecular & Cellular Biology
Calendar Biochemistry and Molecular & Cellular Biology, Department of
» Information about this calendar
» Other events on this calendar
» All events on the Master Calendar

Navigation bar Navigation bar
Georgetown University Search: Full text search Site Index: Find a web site by name or keyword Site Map: Overview of main pages Directory: Find a person; contact us About this site: Copyright, disclaimer, policies, terms of use