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News, Calendars, and Events » Calendars » Master Calendar » Biochemistry and Molecular & Cellular Biology, Department of
Seminar Series: Dr. Mary Helen Barcellos-Hoff
Schedule information
Event Seminar Series: Dr. Mary Helen Barcellos-Hoff
When Tuesday, January 28, 2014 from 12:00pm to 1:00pm
Where Basic Science Building 341 (Library)
Event details
Details “The Tumor Microenvironment, from Cradle to Grave”

Mary Helen Barcellos-Hoff, Ph.D.
Professor, Departments of Radiation Oncology and Cell Biology
New York University School of Medicine

Abstract: Human breast cancer comprises at least six transcriptional subtypes, each with distinct molecular programs. We established a mouse model in which the mammary gland is transplanted with Trp53 null mammary epithelium that undergoes a high rate of spontaneous transformation that generates histologically and molecularly diverse tumors. Comparison of tumors arising in genetically or biologically distinct syngeneic hosts demonstrates that host biology determines the predominant mammary tumor intrinsic subtype. For example, exposure to radiation, a risk factor for breast cancer, of the host prior to transplantation with unirradiated epithelium promotes estrogen receptor negative mammary cancers in mice, as is observed in women treated with radiation as children. The human orthologs of murine transcriptional programs obtained by comparing tumors arising in irradiated hosts to sham-irradiated hosts segregates both radiation preceded human cancers and ER-negative sporadic human breast cancers. I will discuss the use of this model to provide novel insights into the origin of intrinsic subtypes by mechanism operating on the tissue, and hence, the tumor microenvironment.
Access » This event has been marked as open to the public.
Contact Juanita Chipani Biochemistry and Molecular & Cellular Biology office, x71512
Sponsors Department of Biochemistry and Molecular & Cellular Biology
Calendar Biochemistry and Molecular & Cellular Biology, Department of
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